Motif ID: SOX{8,9,10}.p2

Z-value: 0.945


Transcription factors associated with SOX{8,9,10}.p2:

Gene SymbolEntrez IDGene Name
SOX10 6663 SRY (sex determining region Y)-box 10
SOX8 30812 SRY (sex determining region Y)-box 8
SOX9 6662 SRY (sex determining region Y)-box 9

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SOX10chr22_-_36710484-0.194.9e-01Click!
SOX8chr16_+_972064-0.175.2e-01Click!
SOX9chr17_+_676287490.155.7e-01Click!


Activity profile for motif SOX{8,9,10}.p2.

activity profile for motif SOX{8,9,10}.p2


Sorted Z-values histogram for motif SOX{8,9,10}.p2

Sorted Z-values for motif SOX{8,9,10}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX{8,9,10}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_105511615 1.679 NM_001004317
 LIN28B
lin-28 homolog B (C. elegans)
chr6_-_128883125 1.197 NM_002844
NM_001135648
 PTPRK

protein tyrosine phosphatase, receptor type, K

chr2_+_101680594 1.013 NM_004834
NM_145686
NM_145687
 MAP4K4


mitogen-activated protein kinase kinase kinase kinase 4


chr20_-_38751289 0.844 NM_005461
 MAFB
v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)
chr1_-_117011824 0.833 NM_001007237
NM_001542
 IGSF3

immunoglobulin superfamily, member 3

chr12_+_52665196 0.759 NM_017409
 HOXC10
homeobox C10
chr1_-_12599934 0.684 NM_004753
 DHRS3
dehydrogenase/reductase (SDR family) member 3
chr10_-_123346148 0.645 NM_001144915
 FGFR2
fibroblast growth factor receptor 2
chr17_-_37196463 0.642 NM_002230
NM_021991
 JUP

junction plakoglobin

chr20_-_39680405 0.641 NM_032221
 CHD6
chromodomain helicase DNA binding protein 6
chr11_-_27450808 0.616 NM_018490
 LGR4
leucine-rich repeat containing G protein-coupled receptor 4
chr19_+_12810258 0.603 NM_014975
 MAST1
microtubule associated serine/threonine kinase 1
chr17_+_44325127 0.596 NM_001002027
NM_005175
 ATP5G1

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)

chr6_-_10523424 0.579 NM_003220
 TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr16_-_30841938 0.579 NCRNA00095
non-protein coding RNA 95
chr6_+_132000134 0.576 NM_005021
 ENPP3
ectonucleotide pyrophosphatase/phosphodiesterase 3
chr20_+_29656744 0.573 NM_002165
NM_181353
 ID1

inhibitor of DNA binding 1, dominant negative helix-loop-helix protein

chr16_+_21518633 0.572 METTL9
methyltransferase like 9
chr8_-_29262240 0.556 NM_057158
 DUSP4
dual specificity phosphatase 4
chr16_+_67698943 0.554 NM_005329
 HAS3
hyaluronan synthase 3

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 24 entries
enrichment   p-value GO term description
2.53 4.40e-02 GO:0006334 nucleosome assembly
2.47 3.02e-02 GO:0034728 nucleosome organization
1.73 3.18e-02 GO:0007264 small GTPase mediated signal transduction
1.67 2.60e-02 GO:0048646 anatomical structure formation involved in morphogenesis
1.52 8.76e-03 GO:0051128 regulation of cellular component organization
1.51 2.99e-02 GO:0071844 cellular component assembly at cellular level
1.45 1.02e-02 GO:0022607 cellular component assembly
1.39 4.63e-02 GO:0010604 positive regulation of macromolecule metabolic process
1.36 5.92e-03 GO:0006996 organelle organization
1.28 3.71e-03 GO:0071842 cellular component organization at cellular level
1.24 4.47e-04 GO:0032502 developmental process
1.24 1.16e-03 GO:0007275 multicellular organismal development
1.24 2.13e-03 GO:0016043 cellular component organization
1.24 1.76e-02 GO:0048731 system development
1.24 3.30e-02 GO:0071841 cellular component organization or biogenesis at cellular level
1.23 1.12e-02 GO:0048856 anatomical structure development
1.21 1.79e-02 GO:0071840 cellular component organization or biogenesis
1.20 5.09e-03 GO:0051716 cellular response to stimulus
1.18 2.73e-03 GO:0032501 multicellular organismal process
1.17 2.42e-05 GO:0050794 regulation of cellular process

Gene overrepresentation in compartment category:

Showing 1 to 14 of 14 entries
enrichment   p-value GO term description
2.84 1.35e-02 GO:0000786 nucleosome
1.81 3.95e-02 GO:0000785 chromatin
1.36 6.12e-03 GO:0005654 nucleoplasm
1.32 1.20e-03 GO:0031981 nuclear lumen
1.29 2.04e-03 GO:0044428 nuclear part
1.25 1.59e-02 GO:0043233 organelle lumen
1.24 2.09e-02 GO:0031974 membrane-enclosed lumen
1.21 8.20e-07 GO:0005634 nucleus
1.10 2.71e-03 GO:0043227 membrane-bounded organelle
1.10 2.76e-03 GO:0043231 intracellular membrane-bounded organelle
1.09 1.66e-03 GO:0043226 organelle
1.09 2.31e-03 GO:0043229 intracellular organelle
1.08 7.29e-05 GO:0005622 intracellular
1.08 8.72e-05 GO:0044424 intracellular part

Gene overrepresentation in function category:

Showing 1 to 3 of 3 entries
enrichment   p-value GO term description
1.38 4.43e-02 GO:0001071 nucleic acid binding transcription factor activity
1.38 4.43e-02 GO:0003700 sequence-specific DNA binding transcription factor activity
1.13 1.93e-03 GO:0005515 protein binding